ERS International Congress, Madrid 2019

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Citations should be made in the following way: Authors. Title. Eur Respir J 2019; 54: Suppl. 63, abstract number.

New molecular signatures in COPD, lung cancer and a1-antitrypsin deficiency

Thematic Poster
Chairs: G. Beltramo (Dijon, France), A. Mailleux (Paris, France), A. Tiotiu (Nancy, France), T. Maes (Ghent, Belgium)

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A genome-wide association study on the risk variations for susceptibility to early COPD Y. LEE (Seoul, Republic of Korea), J. Lee (Seoul, Republic of Korea), E. Heo (Seoul, Republic of Korea), H. Chung (Seoul, Republic of Korea), D. Kim (Seoul, Republic of Korea)
Irisin secreted from muscle by exercise ameliorates emphysema of cigarette smoke-induced COPD in mice. H. Kubo (Osaka, Japan), K. Asai (Osaka, Japan), A. Miyamoto (Osaka, Japan), H. Kadotani (Osaka, Japan), N. Maruyama (Osaka, Japan), K. Kojima (Osaka, Japan), A. Sugitani (Osaka, Japan), Y. Kyomoto (Osaka, Japan), A. Okamoto (Osaka, Japan), K. Yamada (Osaka, Japan), T. Watanabe (Osaka, Japan), T. Kawaguchi (Osaka, Japan), K. Hirata (Osaka, Japan)
Metabolomic analysis of severe COPD. Study of biomarkers in the CHAIN cohort. C. Gotera (Madrid, Spain), A. Pereira Vega (Huelva, Spain), T. García Barrera (Huelva, Spain), J. Marín Trigo (Zaragoza, Spain), C. Casanova Macario (Santa Cruz de Tenerife, Spain), B. García-Cosío Piqueras (Palma de Mallorca, Spain), I. Mir Viladrich (Palma de Mallorca, Spain), I. Solanes García (Barcelona, Spain), J. Gómez Ariza (Huelva, Spain), J. López Campos (Sevilla, Spain), L. Seijo Maceiras (Madrid, Spain), N. Feu Collado (Cordoba, Spain), C. Cabrera Lopez (Las Palmas de Gran Canarias, Spain), R. Agüero Balbin (Santander, Spain), A. Romero Plaza (Islas Baleares, Spain), J. De Torres Tajes (Pamplona, Spain), L. Padrón Fraysse (Huelva, Spain), B. Callejón Leblic (Huelva, Spain), E. Márquez Martín (Sevilla, Spain), M. Marín Royo (Castellón, Spain), E. Balcells Vilarnau (Barcelona, Spain), A. Llunel Casanova (Barcelona, Spain), C. Martínez González (Oviedo, Spain), J. Galdiz Iturri (Baracaldo, Spain), C. Lacárcel Bautista (Jaén, Spain), G. Peces-Barba (Madrid, Spain)
Associations of an intron MMP9 polymorphism and the serum levels of gelatinase B with the development of COPD T. Tacheva (Stara Zagora, Bulgaria), D. Dimov (Stara Zagora, Bulgaria), Y. Zhelyazkova (Stara Zagora, Bulgaria), D. Vlaykova (Stara Zagora, Bulgaria), G. Beev (Stara Zagora, Bulgaria), T. Vlaykova (Stara Zagora, Bulgaria)
Role of Parkin in the pathogenesis of COPD-related sarcopenia A. Ito (Tokyo, Japan), M. Hashimoto (Tokyo, Japan), J. Tanihata (Tokyo, Japan), T. Nakano (Tokyo, Japan), Y. Hosaka (Tokyo, Japan), A. Ichikawa (Tokyo, Japan), N. Saito (Tokyo, Japan), M. Yoshida (Tokyo, Japan), Y. Fujita (Tokyo, Japan), S. Minagawa (Tokyo, Japan), T. Numata (Tokyo, Japan), H. Hara (Tokyo, Japan), J. Araya (Tokyo, Japan), Y. Kaneko (Tokyo, Japan), K. Kuwano (Tokyo, Japan)
Sirtuin3 reduces acute lung inflammation and emphysematous aggravation in COPD exacerbation mouse model T. Ishimori (Tokyo, Japan), A. Mitani (Tokyo, Japan), S. Kohno (Tokyo, Japan), S. Nagoshi (Tokyo, Japan), M. Saito (Tokyo, Japan), H. Isago (Tokyo, Japan), H. Tamiya (Tokyo, Japan), Y. Mikami (Tokyo, Japan), T. Ishii (Tokyo, Japan), T. Jo (Tokyo, Japan), G. Tanaka (Tokyo, Japan), T. Nagase (Tokyo, Japan)
Impact of polymorphisms in genes involved in nicotine dependence pathways on the smoking burden of COPD patients I. Costa Da Silva (Sao Paulo, Brazil), F. Arrabal Fernandes (Sao Paulo, Brazil), C. Dinardo (Sao Paulo, Brazil), R. Carvalho-Pinto (Sao Paulo, Brazil), C. Farias (Sao Paulo, Brazil), A. Cukier (Sao Paulo, Brazil)
CCL5 rs2280788 polymorphism increased the risk of COPD in the Belarusian population C. Khotko (Minsk, Belarus), A. Kadushkin (Minsk, Belarus), A. Tahanovich (Minsk, Belarus), A. Migas (Minsk, Belarus)
Reactive sulfur species are involved in cigarette smoke-induced cellular senescence S. Yamanaka (Sendai, Japan), T. Ichikawa (Sendai, Japan), H. Sugiura (Sendai, Japan), T. Numakura (Sendai, Japan), H. Sano (Sendai, Japan), M. Yamada (Sendai, Japan), N. Fujino (Sendai, Japan), R. Tanaka (Sendai, Japan), Y. Kyogoku (Sendai, Japan), T. Akaike (Sendai, Japan), M. Ichinose (Sendai, Japan)
Hypoxic lung cancer-derived exosome decreases anticancer activity of NK cell by targeting CD226 Y. Hsu (Kaohsiung, Taiwan), . Hung (Kaohsiung, Taiwan), S. Jian (Kaohsiung, Taiwan)
The role of HER-2/neu, p53, Bcl-2 and Ki-67 in patients with lung cancer B. Ilievska Poposka (Skopje, North Macedonia), S. Smickova (Skopje, North Macedonia), G. Petrusevska (Skopje, North Macedonia)
Metal elements as early biomarkers of lung cancer B. Urizar Catalan (Huelva, Spain), L. Padrón Fraysse (Huelva, Spain), B. Callejón-Leblic (Huelva, Spain), S. García Garrido (Huelva, Spain), V. Ignacio Barrios (Huelva, Spain), J. Gómez Ariza (Huelva, Spain), M. Morón Ortíz (Huelva, Spain), T. García-Barrera (Huelva, Spain), A. Pereira Vega (Huelva, Spain)
The EGFR mutation detection in NSCLC by Next Generation Sequencing (NGS): cons and pros S. Rudzinski (Warsaw, Poland), A. Szpechcinski (Warsaw, Poland), J. Moes-Sosnowska (Warsaw, Poland), K. Duk (Warsaw, Poland), A. Zdral (Warsaw, Poland), U. Lechowicz (Warsaw, Poland), P. Rudzinski (Warsaw, Poland), W. Kupis (Warsaw, Poland), E. Szczepulska-Wójcik (Warsaw, Poland), R. Langfort (Warsaw, Poland), T. Orlowski (Warsaw, Poland), J. Chorostowska-Wynimko (Warsaw, Poland)
Rare SERPINA1 allele Mwhitstable in patients with Alpha1-antitrypsin deficiency V. Barzon (Pavia, Italy), A. Balderacchi (Pavia, Italy), S. Ottaviani (Pavia, Italy), A. Corsico (Pavia, Italy), I. Ferrarotti (Pavia, Italy)
Alpha 1 Antitrypsin Deficiency molecular mechanisms in liver organoids G. GOMEZ MARIANO (Madrid, Spain), N. Matamala (Madrid, Spain), S. Martínez (Madrid, Spain), I. Justo (Madrid, Spain), A. Marcacuzco (Madrid, Spain), C. Jiménez (Madrid, Spain), M. Huch (Cambridge, United Kingdom), B. Martínez-Delgado (Madrid, Spain)
Neutrophil degranulation and oxidative profile in patients with alpha-1 antitrypsin deficiency under hypoxic conditions M. Magallón Serrano (Valencia, Spain), D. Pellicer (Valencia, Spain), S. Castillo (Valencia, Spain), L. Bañuls (Valencia, Spain), M. Navarro-García (Valencia, Spain), A. Escribano (Valencia, Spain), F. Dasi Fernandez (Valencia, Spain)
Patients with Alpha-1 antitrypsin Deficiency due to Null mutations have clinical peculiarities and should require personalized pulmonary management I. Ferrarotti (Pavia, Italy), S. Ottaviani (Pavia, Italy), E. Paracchini (Veruno, Italy), D. Piloni (Pavia, Italy), F. Mariani (Pavia, Italy), G. Paone (Rome, Italy), A. Balderacchi (Pavia, Italy), V. Barzon (Pavia, Italy), M. Bosio (Pavia, Italy), Z. Kadija (Pavia, Italy), B. Balbi (Veruno, Italy), A. Corsico (Pavia, Italy)
Comparison of different algorithms in laboratory diagnosis of Alpha1-antitripsin deficiency A. Balderacchi (Pavia, Italy), V. Barzon (Pavia, Italy), S. Ottaviani (Pavia, Italy), M. Gorrini (Pavia, Italy), A. Corsico (Pavia, Italy), M. Zorzetto (Pavia, Italy), I. Ferrarotti (Pavia, Italy)