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International Congress Munich 2014

Saturday, 06.09.2014 Sunday, 07.09.2014 Monday, 08.09.2014 Tuesday, 09.09.2014 Wednesday, 10.09.2014		Sponsored symposia: Boehringer Ingelheim Evening Symposium: "Identifying the unmet needs in asthma: Who, why and how many?" Bayer Expert Forum: “Infection, Exacerbation and Colonisation: Managing Pseudomonas aeruginosa in Non-CF Bronchiectasis”

Citations should be made in the following way: Authors. Title. Eur Respir J 2014; 44: Suppl. 58, abstract number.

Novel targets and drugs for asthma and COPD

Oral Presentation
Chairs: G. Brusselle (Ghent, Belgium), H. Reddel (Glebe, Australia)

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Characteristics of the adult corticosteroid-dependent severe asthma in UBIOPRED consortium A. R. Sousa, I. Pandis, Y. Xian, U. Hoda, A. Rowe, J. Corfield, E. Jeyasingham, A. Bansal, W. Seibold, A. Wagener, P. Bakke, G. Roberts, F. Singer, U. Frey, H. Ildikó, R. Polosa, N. Krug, R. Middelveld, S. E. Dahlen, J. Musial, D. Gibeon, L. Fleming, S. Fowler, L. Pahus, D. Shaw, P. Howarth, D. Myles, C. Compton, T. Higenbottam, P. Montuschi, J. Vestbo, U. Nihlen, T. Sandström, S. Wagers, R. Djukanovic, E. Bel, P. Sterk, F. Chung (London, Southampton, Nottingham, Manchester, Cambridge, United Kingdom; San Diego, United States Of America; Basel, Bern, Switzerland; Krakow, Poland; Amsterdam, Netherlands; Marseille, France; Roma, Catania, Italy; Hvidovre, Denmark; Budapest, Hungary; Hamburg, Ingelheim, Germany; Bergen, Norway; Umeå, Stockholm, Sweden; Maasmechelen, Belgium)
ADEPT-derived, U-BIOPRED validated asthma clinical clusters with Th2 and non-Th2 phenotypes M. Loza, P. Silkoff, V. Susilic, A. Rowe, I. Adcock, C. Auffray, K. F. Chung, R. Djukanovic, P. Sterk, F. Baribaud (Spring House, United States Of America; London, Southampton, United Kingdom; Lyon, France; Amsterdam, Netherlands)
In vitro pharmacological characterization of CHF6001, a novel selective phosphodiesterase 4 (PDE4) inhibitor with a robust anti-inflammatory profile F. Facchinetti, N. Moretto, P. Caruso, G. Marchini, R. Bosco, C. Carnini, M. Civelli, G. Villetti (Parma, Italy)
Anti-inflammatory effects of the novel phosphodiesterase type 4 inhibitor CHF6001 on COPD alveolar macrophages and lung tissue S. Lea, A. Metryka, F. Facchinetti, M. Civelli, G. Villetti, D. Singh (Manchester, United Kingdom; Parma, Italy)
Enhanced inflammatory gene expression in bronchial epithelial cells from asthmatic patients: Attenuation by a Brd4 mimic P. Brook, A. Durham, I. Adcock (London, United Kingdom)
In vitro pharmacological characterization of two novel dual-acting MABA compounds (LAS190792 and LAS191351) M. Miralpeix, C. Carcasona, I. Ramos, C. Puig, D. Vilella, A. Gavaldà, M. Aparici (Barcelona, Spain)
Bronchoprotective activity and safety assessment of two novel dual-acting MABA compounds (LAS190792 and LAS191351) in dogs A. Gavaldà, M. Aparici, J. L. Montero, C. Puig, C. Doe, M. Miralpeix (Barcelona, Spain)
CRAC channel inhibition by RP3128 ameliorates airway hyper-reactivity in antigen sensitized mice and guinea pigs K. Routhu, B. Govindrajulu, S. Veeraraghavan, S. Viswanadha, S. Vakkalanka (Hyderabad, India)

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