The aims of the research seminar were:

Summarise the current knowledge regarding clinical trial outcomes for infants and preschool children with cystic fibrosis
Review regulatory requirements for trial endpoints in infants and young children
Identify gaps in knowledge and information required

Introduction - setting the scene S. Stick (Perth, Australia)
Computerised tomography (CT) – Gold standard for structural lung disease in young children with CT? H. Tiddens (Rotterdam, Netherlands)
Image analysis and scoring in young children S. Stick (Perth, Australia), H. Tiddens (Rotterdam, Netherlands)
CT dose – optimising the risk to benefit ratio M. Van Straten (, Netherlands)
Surrogate outcome measures F. Ratjen (Toronto, Canada)
Bronchoalveolar lavage (BAL) to monitor disease progression P. Sly (Herston, Australia)
Raised volume rapid thoracic compression S. Ranganathan (Parkville, Australia)
Lung Clearance Index (LCI) P. Gustafsson (Skovde, Sweden)
Spirometry P. Aurora (London, United Kingdom)
Introduction H. Tiddens (Rotterdam, Netherlands)
Workshop 3 - Pulmonary Function Tests P. Aurora (London, United Kingdom), M. Rosenfeld (Seattle, Wa, United States of America)
Workshop - A strategy to acquire the data that will satisfy regulatory bodies S. Stick (Perth, Australia)