Repair and regeneration in chronic lung disease and lung cancer, Virtual 2021

The Lung Science Conference is at the forefront of basic and translational respiratory science and it is an essential event for budding respiratory researchers looking to boost their career.

Educational aims

To present the very best of international lung science research
To highlight new discoveries likely to impact on the future of respiratory medicine
To encourage debate and interaction between young postdoctoral scientists and established investigators

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Welcome and Introduction Reinoud Gosens (Groningen, Netherlands)
Opening Lecture: Is human pulmonary fibrosis simply lung regeneration without a blueprint? Naftali Kaminski (New Haven, United States of America)
iPSC derived lung stem cells as tools to understand lung regeneration and disease Killian Hurley (Co. Meath, Ireland)
The journey of stem cell differentiation during alveolar regeneration Joo-Hyeon Lee (Cambridge, United Kingdom)
Macrophage plasticity in COPD Joachim Schultze (Bonn, Germany)
Epithelial-mesenchymal interactions involving FGFs Saverio Bellusci (Giessen, Germany)
The role of the microvascular niche in lung regeneration Edward Morrisey (Philadelphia, United States of America)
Poster session 1 - Group A
Poster session 1 - Group B
Poster session 1 - Group C
Poster session 1 - Group D
Poster session 2 - Group E
Poster session 2 - Group F
Poster session 2 - Group G
Poster session 2 - Group H
Early-Career delegates session - Introduction Niki Ubags (Epalinges, Switzerland)
The use of Pre-prints to publish your science Darcy Wagner (Lund, Sweden)
How to write a peer review Pieter S. Hiemstra (Leiden, Netherlands)
How to make me like your paper (part 1) Martin Kolb (Hamilton (ON), Canada)
How to make me like your paper (part 2) Susanne Herold (Gießen, Germany)
Early-Career delegates session - Panel discussion
Tobacco smoking and somatic mutations in human bronchial epithelium Sam Janes (London, United Kingdom)
Club cells in adenocarcinoma and alveolar repair Georgios Stathopoulos (Munich, Germany)
Young Investigator Session – The William MacNee Award
Uncovering the cells and genes responsible for salamander limb regeneration Nicholas Leigh (Lund, Sweden)
Cell-matrix interactions in chronic lung disease Janette K. Burgess (Groningen, Netherlands)
Regulation of cell fate and integrity by mechanical signals Sara Wickström (Helsinki, Finland)
Lung organoids reveal epithelial-mesenchymal mechanisms of lung disease and potential therapy Carla Kim (Boston, United States of America)
Mesenchymal stem cell therapy for severe emphysema Pieter S. Hiemstra (Leiden, Netherlands)
Cellular reprogramming of cancer cells to antigen-presenting cells Filipe Pereira (Lund, Sweden)
Awards announcement and conclusion Reinoud Gosens (Groningen, Netherlands)
PP101 – Short-range interactions between fibrocytes and CD8+ T cells modulate the balance between tissue repair and destruction in COPD Isabelle Dupin, France
PP102 – A serum biomarker reflecting human neutrophil elastase degraded calprotectin is elevated in COPD and IPF Annika Hummersgaard Hansen, Denmark
PP103 – Dysregulation of ZFP36L1 and ZFP36L2 in asthma alters epithelial integrity and genome-wide glucocorticoid responses Rocio Teresa Martinez-Nunez, United Kingdom
PP104 – Whole transcriptome analysis on lungs of house dust mite-exposed IGF1Rdeficient mice provides new insights in allergic airway inflammation Alfredo Urtubia, Spain
PP105 – Single-cell transcriptome analysis reveals an anomalous epithelial variation and ectopic inflammatory response in COPD Naoaki Watanabe, Japan
PP106 – Identification of HuR-specific RNA interactome in TGFß1-activated fibroblasts in response to cigarette smoke Sofia Winslow, Sweden
PP107 – 3D printing aids simultaneous isolation of proximal and distal lung epithelial progenitors from individual mice Hani N. Alsafadi, Sweden
PP108 – Role of TRIM-16-mediated lysophagy in COPD pathogenesis Yusuke Hosaka, Japan
PP109 – Coxsackie and Adenovirus Receptor (CAR) controls lung epithelial cell responses to inflammation Elena Ortiz Zapater, United Kingdom
PP110 – Modulation of the TGF-ß-induced epithelial-to-mesenchymal transition by panselective PDE inhibitors in A549 cells Katarzyna Wójcik-Pszczola, Poland
PP111 – PGE2 and PGI2 restore defective lung epithelial progenitors induced by cigarette smoke Xinhui Wu, Netherlands
PP112 – Itaconate regulates responses to inhaled aeroallergen Gesa Albers, United Kingdom
PP113 – Epidermal growth factor receptor in airway remodelling during allergic airway disease – divergent roles during early life and adulthood? Helen Stölting, United Kingdom
PP114 – Mesenchymal stromal cells reduce house dust mite induced allergic airway inflammation in a humanised MIF expressing mouse model Ian Hawthorne, Ireland
PP115 – COL4A3 degradation predicts anti-IgE response in severe asthma Markus Weckmann, Germany
PP116 – Associations between pediatric asthma and adult lung diseases Nirmin Juber, Taiwan
PP117 – Household use of biomass fuel is associated with childhood wheeze and eczema: a cross sectional study of rural communities in Kandy, Sri Lanka Olivia Lall, Australia
PP118 – Ambient PM2.5 Exposure and Respiratory Disease Hospitalization in Kandy, Sri Lanka Gayan Bowatte, Sri Lanka
PP119 – COL4A3 expression in asthmatic epithelium depends on intronic methylation and ZNF263 binding Sai Sneha Priya Nemani, Germany
PP120 – Smoking alters gene expression and methylation patterns in asthma patient nasal epithelium Karosham (Diren) Reddy, Australia
PP121 – Gaq/11 and Ga12/13 promote pulmonary fibrosis by driving distinct myofibroblast functions Amanda Goodwin, United Kingdom
PP122 – AT2 cell delivery using rECM microcarriers for COPD treatment Deniz Ali Bölükbas, Sweden
PP123 – Dimethyl fumarate attenuates lung inflammation and oxidative stress induced by chronic exposure to diesel exhaust particles in mice Isabella Cattani-Cavalieri, Netherlands
PP124 – Establishment of a human in vitro model for airway epithelial repair and regeneration Ashesh Chakraborty, Germany
PP125 – Glycogen synthase kinase-3 inhibition by CHIR99021 promotes alveolar epithelial cell proliferation and lung regeneration in acute lung injury Raquel Fernandes, Portugal
PP126 – RANKL contributes to lung tissue repair via promoting type II epithelial cell proliferation Habibie Habibie, Netherlands
PP127 – Three-dimensional niches for the physiological-like expansion of a lung mesenchymal stromal cell subpopulation Arturo Ibáñez Fonseca, Sweden
PP128 – Investigating the role of vitamin A intake and retinoic acid signalling in lung homeostasis and repair-A multidisciplinary approach Róisín Mongey, United Kingdom
PP129 – Safety evaluation of cancer immunotherapy in a lung-on-chip model: the therapeutic FOLR1 targeting T Cell Bispecific antibody Giulia Raggi, Switzerland
PP130 – Spatial characteristics of CD169+ resident conducting airway macrophages during Aspergillus fumigatus-induced inflammation Marina Shevchenko, Russia
PP131 – Macrophages in lung adenocarcinoma Giannoula Ntaliarda, Greece
PP132 – Reversible fetal tracheal occlusion in mice: a novel transuterine method Nilhan Torlak, Turkey
PP133 – IGF1R acts in the tumor microenvironment as a cancer-promoting factor facilitating the implantation and progression of lung metastasis Elvira Alfaro Arnedo, Spain
PP134 – Mapping of Kras mutations during chemical carcinogenesis Sabine Behrend, Germany
PP135 – Mutational RNA signatures in environmentally-induced lung adenocarcinoma Georgia A. Giotopoulou, Germany
PP136 – Preclinical evaluation of IL-1ß inhibition against KRAS-mutant lung adenocarcinoma Georgios Skiadas, Greece
PP137 – Airway cells in adult lung homeostasis and carcinogenesis Magda Spella, Greece
PP138 – Regulation of PA200 in lung cancer Ayse Seda Yazgili, Germany
PP201 – Therapeutic targeting of iBALT induces lung regeneration in COPD Thomas Conlon, Germany
PP202 – Recreating the 3D environment for airway fibroblasts and epithelial cells with lung extracellular matrix derived hydrogels Roderick H.J. de Hilster, Netherlands
PP203 – Club cell functions as a Wnt-responsive progenitor for tissue repair in COPD Yan Hu, USA
PP205 – Effect of mTOR inhibition in a 3D in vitro model of alveolar epithelium and epithelial regeneration Manuela Platé, United Kingdom
PP206 – Modeling idiopathic pulmonary fibrosis using induced pluripotent stem cell-derived alveolar epithelial organoids Victoria Ptasinski, Sweden
PP207 – Targeting p16INK4a in alveolar type 2 cells to induce endogenous lung alveolar regeneration Bruno Ribeiro Baptista, France
PP208 – SRC family kinases modulate molecular pathways associated with mitochondrial dysfunction in idiopathic pulmonary fibrosis Carmen Veith, Germany
PP209 – Mitochondrial DNA stress activates MHC class I antigen presentation and CD8+ Tcell immunity: implications for pulmonary fibrosis Xinyuan Wang, Germany
PP211 – Galectin-3 is elevated following nintedanib treatment Gali Epstein Shochet, Israel
PP212 – The Anti-Fibrotic Drug Nintedanib Promotes Repair Macrophages Carolin Koss, Germany
PP213 – Adoptive transfer of hepatocyte growth factor transfected T cells in a bleomycin injured murine lung model Seyran Mutlu, Switzerland
PP214 – Human precision-cut lung slices generated from excess donor lungs as a model for IPF and drug screening John Stegmayr, Sweden
PP215 – The effect of long-term personal air pollution exposure on the inflammatory mediators in Idiopathic Pulmonary Fibrosis Ioannis Tomos, Greece
PP216 – Glucocorticoids exacerbate TGFß1 mediated fibrotic signalling in lung fibroblasts by inhibition of metalloproteinase expression and activity Muzamil Majid Khan, Germany
PP217 – Modeling idiopathic pulmonary fibrosis on a lung-on-chip Lea de Maddalena, Switzerland
PP218 – Direct effects of cigarette smoke in pulmonary arterial cells: Implications in arterial remodeling and vascular tone maintenance Javier Sevilla-Montero, Spain
PP219 – Development and Validation of a Novel Prognostic Nomogram for COPD patients with Pulmonary Hypertension Dansha Zhou, China
PP220 – Hypercoagulability in patients with stable COPD assessed by coagulation factor levels Chris Kyriakopoulos, Greece
PP221 – EZH2-dependent transcriptional complex promotes aberrant epithelial remodelling after injury Huy Le, Germany
PP222 – Forkhead Box F1 as a mediator of Wnt signaling in human lung endothelial cells Gabriëla Edel, Netherlands
PP223 – N-Acetyl cysteine rescues neonatal lethality caused by HRas/NRas deficiency by improving lung maturation and decreasing oxidative stress Rocío Fuentes Mateos, Spain
PP225 – Development of a 3D in vitro co-culture model of the airway mucosa using human primary cells Cinta Iriondo, Netherlands
PP226 – Decellularized extracellular matrix hydrogels for human airway organoid culture Sinem Tas, Sweden
PP227 – Paper-based biosensor for the detection of sepsis murine using MMP9 and a9ß6, integrons RI Class1 and R2 Class 2 peptides Nuha Alekhmimi, Saudi Arabia
PP228 – Chest CT findings on admission of COVID-19 pneumonia and its association with disease severity and duration of illness: a retrospective study Eleanor Dela Pena, Philippines
PP229 – Clinical profile of 116 patients undergoing post-COVID follow-up - A prospective study Pranav Modi, India
PP230 – Functional profiling and visualization of stromal cell dynamics in the influenza virus infected lung Julie Worrell, United Kingdom
PP231 – Released mediators in ex vivo 3D-model of lung fibrosis correspond to elevated serum biomarkers in IPF Dimitrios Kalafatis, Sweden
PP232 – IL11 negatively impacts adult lung alveolar organoid formation Rosa K. Kortekaas, Netherlands
PP233 – Crosstalk between lung fibroblasts and mast cells is modified by alveolar extracellular matrix and influences epithelial migration Anna-Karin Larsson-Callerfelt, Sweden
PP234 – Lung-on-a-chip device for modelling of ventilator induced lung injury Emil Rehnberg, Sweden
PP236 – Elastin-like-recombinamer cryogel as a platform for lung regeneration Zackarias Söderlund, Sweden
PP237 – D-dopachrome tautomerase contributes to lung epithelial repair via ACKR3- dependent Akt signalling Shanshan Song, Netherlands
PP238 – Role of mitochondrial function of lung mesenchymal stem cells in idiopathic pulmonary fibrosis Joan Truyols, Spain
PP239 – Decellularised porcine pleural patches for management of prolonged alveolar air leaks Trisha Vikranth, United Kingdom
PP240 – COL4A3 degradation is increased in severe, type 2 exacerbating asthmatics Markus Weckmann, Germany
PP301 – The role of the systemic inflammation in bronchiectasis exacerbation frequency Kseniia Suska, Ukraine
PP302 – The relationship between the level of C-reactive protein and the general cardiovascular risk in patients with COPD and hypertension Olha Boiko, Ukraine
PP303 – Effects of mild to moderate asthma in pregnancy on the wellbeing of mother and newborn; A case control study from Sri Lanka Duminda Yasaratne, Sri Lanka
PP304 – The effect of exercises on flat and sloping levels on muscle mass and functional capacity in chronic obstructive pulmonary disease patients Samira Nakhaie, Iran
PP305 – Can Hematological Ratios Predict Outcome of COVID-19 Patients? Egyptian Multicentric Study Mai Aly, Egypt
PP306 – Submicroscopic changes of type I alveolocytes in the early stages of experimental diabetes mellitus Yuliya Fedorchenko, Ukraine
PP307 – The role of microalbuminuria (MAB) in patients admitted for an Acute COPD Exacerbation (AECOPD) Chris Kyriakopoulos, Greece
PP308 – Endothelial injury in Chronic Obstructive Pulmonary Disease assessed by microalbuminuria (MAB) and von Willebrand factor levels and activity Chris Kyriakopoulos, Greece
PP309 – Effect of elexacaftor-tezacaftor-ivacaftor on pulmonary and endothelial function in a patient with advanced cystic fibrosis Saša Rink, Slovenia
PP310 – Association of testosterone with lung function in patients with chronic obstructive lung disease Abir Hedhli, Tunisia
PP311 – Nontypeable Haemophilus influenzae supresses SP-B and SP-C expression in alveolar epithelial type II cells Hannah Sophie Stodden, Germany
PP312 – Diagnosis of non severe pulmonary embolism Salma Aït Batahar, Morocco
PP313 – Agreement between expert sonographers and artificial intelligence in the evaluation of lung ultrasound data acquired from COVID-19 patients Libertario Demi, Italy
YI401 - A comprehensive guide to pulmonary mesenchymal populations in the healthy and IPF lung Simon Coyle Rowan (Dublin, Ireland)
YI402 - Host response towards decellularised lung extracellular matrix reinforced bioinks for 3D bioprinting lung tissue for transplantation Martina M. De Santis (Lund, Sweden)
YI403 - cAMP response element-binding protein mediates immune-evasion of KRASmutant lung adenocarcinoma Georgia A. Giotopoulou (Munich, Germany)
YI404 - Pluripotent stem cell derived airway cholinergic neurons for disease modelling of neuroplasticity in asthma Pien Goldsteen (Groningen, Netherlands)
YI405 - Use of differentiated primary human airway epithelial models to study SARSCoV-2 infection biology and pathogenesis Ying Wang (Leiden, Netherlands)