With the increasing use of newborn screening and the diagnosis of cystic fibrosis in the first weeks of life, researchers have a clear responsibility to develop interventions that will prevent or delay the onset of bronchiectasis that are suitable for use from birth. The Seminar will bring together motivated CF programme directors and leading researchersin order to:

• describe the earliest pathophysiological manifestations of cystic fibrosis lung disease
• evaluate key early clinical outcome measures
• identify critical gaps in knowledge
• prioritise suitable targets for randomised clinical trials
• address issues of network management and clinical trials design