Pulmonary hypertension: promising small molecules

Poster Discussion
Chairs: Christophe Guignabert (le Plessis-Robinson, France), Soni Savai Pullamsetti (Bad Nauheim, Germany)
LSC Abstract – Glutamatergic signaling through pulmonary vascular NMDA receptors in pulmonary hypertension
Sebastien J. Dumas (Le Plessis-Robinson, France), Sébastien J. Dumas, Frédéric Perros, Gilles Bru-Mercier, Audrey Courboulin, Benoit Ranchoux, Catherine Rücker-Martin, Elodie Gouadon, Matthieu Vocelle, Nicolas Raymond, Peter Dorfmüller, Elie Fadel, Marc Humbert, Sylvia Cohen-Kaminsky
Congress or journal article abstract
Congress or journal article abstract
In-situ metabolite profiling of remodeled arteries in Pulmonary Arterial Hypertension (PAH) using innovative mass spectrometry imaging (MSI) tools
Gregory Hamm (Loos, France), Sébastien J. Dumas, Raphael Legouffe, Fabien Pamelard, David Bonnel, Gaël Picard De Muller, Gregory Hamm, Peter Dorfmüller, Elie Fadel, Marc Humbert, Jonathan Stauber, Sylvia Cohen-Kaminsky
Congress or journal article abstract
Congress or journal article abstract
Endothelial-derived MIF contributes to pulmonary endothelial cell proliferation in human pulmonary arterial hypertension
Morane Le Hiress (Le Plessis-Robinson, France), Morane Le Hiress, Ly Tu, Carole Phan, Raphaël Thuillet, Nicolas Ricard, Andrei Seferian, Elie Fadel, Gerald Simonneau, Alice Huertas, Yuichi Tamura, Marc Humbert, Christophe Guignabert
Congress or journal article abstract
Congress or journal article abstract
CD163 is expressed and modulated in human pulmonary artery smooth muscle cells: Implications for pulmonary artery hypertension
Latha Ramakrishnan (London, United Kingdom), Latha Ramakrishnan, Sharon Mumby, John S. Wort, Gregory J. Quinlan
Congress or journal article abstract
Congress or journal article abstract
Role of JAK2/STAT3 pathway in vascular function of pulmonary fibrosis patients
Beatriz Ballester (Burjassot (Valencia), Spain), Beatriz Ballester, Javier Milara, Anselm Morell, Sonia Contreras, Adela Serrano, Sonia González, Julio Cortijo
Congress or journal article abstract
Congress or journal article abstract
Balancing TGFbeta/BMP in pulmonary arterial hypertension
Nina Rol (Amsterdam, Netherlands), Nina Rol, Robert Szulcek, Marie-José Goumans, Chris Dickhoff, Anton Vonk-Noordegraaf, Harm Jan Bogaard, Geerten Van Nieuw Amerongen
Congress or journal article abstract
Congress or journal article abstract
Is arginase a potential drug target in tobacco-induced pulmonary endothelial dysfunction?
Priscilla Henno (Paris, France), Priscilla Henno, Christelle Maurey, Françoise Le Pimpec-Barthes, Philippe Devillier, Christophe Delclaux, Dominique Israël-Biet
Congress or journal article abstract
Congress or journal article abstract
Cystic fibrosis transmembrane conductance regulator and sphingolipids regulate hypoxic pulmonary vasoconstriction
Christoph Tabeling (Berlin, Germany), Christoph Tabeling, Hanpo Yu, Liming Wang, Hannes Ranke, Neil M. Goldenberg, Diana Zabini, Elena Noe, Adrienn Krauszman, Birgitt Gutbier, Jun Yin, Michael Schaefer, Christoph Arenz, Andreas C. Hocke, Norbert Suttorp, Richard L. Proia, Martin Witzenrath, Wolfgang M. Kuebler
Congress or journal article abstract
Congress or journal article abstract
Expression and function of aquaporin 1 in hypoxia-induced pulmonary hypertension
Claudio Schuoler (Zurich, Switzerland), Claudio Schuoler, Thomas Haider, Caroline Leuenberger, Max Gassmann, Malcolm Kohler, Lars Huber, Matthias Brock
Congress or journal article abstract
Congress or journal article abstract
Time-resolved study of endothelial shear-responsiveness in pulmonary arterial hypertension
Robert Szulcek (Amsterdam, Netherlands), Robert Szulcek, Chris Happe, Nina Rol, Ruud Fontijn, Chris Dickhoff, Frances De Man, Anton Vonk-Noordegraaf, Christophe Guignabert, Paul Yu, Geerten Van Nieuw Amerongen, Harm-Jan Bogaard
Congress or journal article abstract
Congress or journal article abstract
The inflammasome adaptor ASC mediates pulmonary artery remodelling
Fadila Telarevic Cero (Oslo, Norway), Fadila Telarevic Cero, Karl Otto Larsen, Vigdis Hillestad, Maria Belland Olsen, Camilla Udjus, Ivar Sjaastad, Arne Yndestad, Pål Aukrust, Else Marit Løberg, Geir Christensen, Ole Henning Skjønsberg
Congress or journal article abstractE-poster
Congress or journal article abstractE-poster
Tryptophan hydroxylase-1 inhibitors reduce serotonin levels and mast cell numbers in monocrotaline-treated rat lungs
William, Zavadoski (New Haven, United States of America), William Zavadoski, Patricia-Ann Bourassa, Nicole Barucci, Qing Zhang, Stephane De Lombaert, Daniel Goldberg, Jeffrey Dubins, Vishwas Paralkar, Robert Aiello
Congress or journal article abstract
Congress or journal article abstract
Temporal hemodynamic and histological changes in a rat model of SUGEN-induced PAH
Vincent Girod (Marseille, France), Vincent Girod, Audrey Bourdet, Sandra Robelet, Adeline Bouzereau, Delphine Revy
Congress or journal article abstract
Congress or journal article abstract
Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing VEGF-A produced by mesenchymal stem cells
David Smadja (Paris, France), David Smadja, Marilyne Levy, Lan Huang, Elisa Rossi, Dominique Israel-Biet, Pascale Gaussem, Joyce Bischoff
Congress or journal article abstract
Congress or journal article abstract
Caspase inhibition stabilizes progressive vascular remodeling in established pulmonary hypertension
Chris Happé (Amsterdam, Netherlands), C.M. Happé, R. Szulcek, N. Rol, M.A. De Raaf, I. Schalij, A. Vonk-Noordegraaf, F.S. De Man, G.P. Van Nieuw-Amerongen, H.J. Bogaard
Congress or journal article abstract
Congress or journal article abstract
Effects of apoptosis signal- regulating kinase 1 (ASK1) inhibition in experimental pressure overload-induced right ventricular dysfunction
Mario Boehm (Giessen, Germany), Mario Boehm, Baktybek Kojonazarov, Hossein Ardeschir Ghofrani, Friedrich Grimminger, Norbert Weissmann, John T. Liles, Grant R. Budas, Werner Seeger, Ralph T. Schermuly
Congress or journal article abstract
Congress or journal article abstract
Selective TSC1 deletion in smooth muscle activates mTOR signaling and induces pulmonary hypertension
Amal Houssaini (Evry, France), Amal Houssaini, Shariq Abid, Geneviève Derumeaux, Feng Wan, Aurélien Parpaleix, Dominique Rideau, Elisabeth Marcos, Kanny Kebe, Gabor Czibik, Diago Sawaki, Caroline Trains, Jean-Luc Dubois-Randé, Zhenlin Li, Valérie Amsellem, Larissa Lipskaia, Mario Pende, Serge Adnot
Congress or journal article abstract
Congress or journal article abstract
Role of the TrkA receptor in experimental severe pulmonary hypertension
Florence Coste (Bordeaux, France), Florence Coste, Christian Toussaint, Mathilde Dubois, Arnaud Courtois, Christelle Guibert, Roger Marthan, Jean-Pierre Savineau, Bernard Muller, Véronique Michel
Congress or journal article abstract
Congress or journal article abstract