Clifford Taggart (Belfast, United Kingdom), Markus Henke (Marburg, Germany)
LATE-BREAKING ABSTRACT: A lung-resident Ly6c+ monocyte proliferates to give rise to immunosuppressive lung macrophages Catherine Sabatel (Sart-Tilman, Belgium), Catherine Sabatel, Coraline Radermecker, Svetoslav Chakarov, Laurence Fiévez, Geneviève Paulissen, Marie Toussaint, Christophe Desmet, Florent Ginhoux, Thomas Marichal, Fabrice Bureau
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HMGB1 is upregulated in ASM in asthma and induces ASM contraction via TLR4 Leonarda Di Candia (Paris, France), Leonarda Di Candia, Ruth Saunders, John Challiss, Christopher Brightling
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Wnt5a – regulator of molecular events leading to inflammation and cancer in the lung Diána Feller (Pécs, Hungary), Diána Feller, Veronika Csöngei, Tamás Kovács, József Kun, Dávid Ernszt, Zsuzsanna Helyes, Judit E Pongrácz
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LSC Abstract – Severity of lung tissue pathology is dictated by S. aureus toxins eliciting series of cytolytic and chemotactic responses Srikanth Mairpady Shambat (Stockholm, Sweden), Srikanth Mairpady Shambat, Puran Chen, Anh-Thu Nguyen Hoang, Francois Vandenesch, Gerard Lina, Ian R. Monk, Timothy J. Foster, Gayathri Arakere, Mattias Svensson, Anna Norrby-Teglund
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Tobacco smoke causes release of IL-16 protein from NK cells in vitro Anders Andersson (Gothenburg, Sweden), Anders Andersson, Carina Malmhäll, Anders Lindén, Apostolos Bossios
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Disease specific effects of adrenomedullin in COPD and asthma derived human bronchial epithelial cells Jyotshna Mandal (Basel, Switzerland), Jyotshna Mandal, Michael Roth, Lukas Bubendorf, Spasenija Savic, Michael Tamm, Daiana Stolz
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Impaired synthesis and transport of immunoglobulin A in severe asthma: Role of IL-13 Maha Zohra Ladjemi (Brussels, Belgium), Maha Zohra Ladjemi, Bruno Detry, Delphine Gras, Marylène Lecocq, Sébastien Dupasquier, Jonathan Mouthuy, Chantal Fregimilicka, Caroline Bouzin, Holly Bowen, Hannah Gould, Pascal Chanez, Charles Pilette
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Cigarette smoke impairs Sirt1 activity and promotes pro-inflammatory responses in bronchial epithelial cells Serena Di Vincenzo (Palermo, Italy), Serena Di Vincenzo, Mark Gjomarkaj, Jacobien Noordhoek, Maria Ferraro, Harold De Bruin, Chiara Cipollina, Dirkje Postma, Irene Heijink, Elisabetta Pace
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Bronchodilator responsiveness is impaired in a mouse model of cigarette smoke exposure and influenza infection Chantal Donovan (Melbourne, Australia), Chantal Donovan, Huei Jiunn Seow, Jane Bourke, Ross Vlahos
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LSC Abstract – A functional variant of secretory leukocyte protease inhibitor (SLPI) with improved anti-inflammatory activity against pulmonary infection Arlene Glasgow (Belfast, United Kingdom), Arlene Glasgow, Nicolas Camper, Megan Osbourn, Derek Quinn, Stuart Elborn, Rebecca Ingram, Sinead Weldon, Clifford Taggart
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Airway epithelial cell IP-10 production is regulated by miR-31 via the transcription factor IRF-1 Sinead Weldon (Belfast, United Kingdom), Lauren Kerrigan, Cliff Taggart, Sinead Weldon
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LSC Abstract – Cigarette smoke exposure accelerates airway mucus accumulation and inflammation in ENaC-overexpressed mice Carolina Ballester Lopez (Munich, Germany), Carolina Ballester Lopez, Jie Jia, Marcus Mall, Oliver Eickelberg, Ali Önder Yildirim
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LSC Abstract – Interleukin-26 in antibacterial host defense of human lungs: Effects on neutrophil mobilization Karlhans Che (Stockholm, Sweden), Karlhans Fru Che, Sara Tengvall, Bettina Levanen, Elin Silverpil, Margaretha Smith, Muhammed Awad, Max Vikström, Lena Palmberg, Ingemar Qvarfordt, Magnus Sköld, Anders Linden
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Azithromycin differentially affects IL-13 induced periostin (POSTN), CLCA1 and SERPINB2 expression in human bronchial epithelial cells Tinne Mertens (Leiden, Netherlands), Tinne Mertens, Pieter Hiemstra, Christian Taube
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Endothelin receptor B protects GM-CSF mRNA from degradation in human airway smooth muscle cells David Jungck (Bochum, Germany), David Jungck, Jürgen Knobloch, Sandra Körber, Yingfeng Lin, Jürgen Konradi, Sarah Yanik, Erich Stoelben, Andrea Koch
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Cigarette smoke extract induces the release of extracellular vesicles by airway epithelial cells via cellular carbonyl stress Birke Benedikter (Maastricht, Netherlands), Birke J. Benedikter, Charlotte Volgers, Guido R.M.M. Haenen, Paul H.M. Savelkoul, Emiel F.M. Wouters, Gernot G.U. Rohde, Antje R. Weseler, Frank R.M. Stassen
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Changes of TNF-a level in bronchoalveolar fluid of patients with chronic obstructive pulmonary disease before and after the 30 days treatment with tiotropium bromide Mariana Kulynych-Miskiv (Galych, Ukraine), Mariana Kulynych-Miskiv, Mykola Ostrovskyy, Oleksandr Varunkiv, Iryna Savelikhina
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The human cathelicidin LL37 and mitochondrial DAMPs induce airway inflammation in epithelial cells and mice Simon D. Pouwels (Groningen, Netherlands), Simon Pouwels, Nick Ten Hacken, Jaap Lubbers, Antoon Van Oosterhout, Martijn Nawijn, Irene Heijink
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