Airway pharmacology: drug targets and mode of action

Poster Discussion
Chairs: Akira Yamasaki (Yonago, Japan), Irene Heijink (Groningen, Netherlands)
Prostacyclin IP receptor activation blocks hyperosmolar-induced bronchoconstriction in isolated human small airways
Jesper Säfholm (Stockholm, Sweden), Jesper Säfholm, Johan Bood, Sven-Erik Dahlén, Mikael Adner
Congress or journal article abstract
Congress or journal article abstract
Monitoring local pulmonary cAMP levels: Combining precision cut lung slice (PCLS) and fluorescence resonance energy transfer (FRET) technologies in mice
Martina Schmidt (Groningen, Netherlands), Martina Schmidt, Haoxio Zuo, Wilfred Jelco Poppinga, Viacheslav Nikolaev
Congress or journal article abstract
Congress or journal article abstract
Olodaterol attenuates bleomycin induced lung fibrosis in mice
Franziska Herrmann (Biberach an der Riss, Germany), Franziska Herrmann, Stefan-Lutz Wollin, Florian Gantner, Eva Wex
Congress or journal article abstractE-poster
Congress or journal article abstractE-poster
Pharmacological characterization of the mechanism of action leading to synergism between glycopyrronium bromide and indacaterol fumarate
Luigino Calzetta (Rome, Italy), Luigino Calzetta, Paola Rogliani, Ermanno Puxeddu, Josuel Ora, Francesco Facciolo, Maria Gabriella Matera, Mario Cazzola
Congress or journal article abstract
Congress or journal article abstract
Slow dissociation kinetics of LAMAs contribute to the functional interactions with LABAs
Loes Kistemaker (Groningen, Netherlands), Reinoud Gosens, Carolina R.S. Elzinga, I. Sophie T. Bos, Herman Meurs, Loes E.M. Kistemaker
Congress or journal article abstract
Congress or journal article abstract
Increased expression of ADRB2, CHRM3 and glucocorticoid alpha receptor genes in blood leukocytes of COPD patients
Alexey Chukhlovin (St Petersburg, Russian Federation), Alexey Chukhlovin, Olga Titova, Nikita Yolshin, Natalya Kuzubova
Congress or journal article abstractE-poster
Congress or journal article abstractE-poster
Neurokinin-1 receptor antagonism for the treatment of cough in lung cancer
Jaclyn Smith (Manchester, United Kingdom), Amelie Harle, Fiona Blackhall, Alex Molassiotis, Kim Holt, Rachel Dockry, Philip Russell, Katy Burns, Ryan Robinson, Mark Birrell, Maria Belvisi, Jaclyn Smith
Congress or journal article abstract
Congress or journal article abstract
Budesonide and fluticasone propionate exertdifferential effects on human bronchial epithelial cells exposed to streptococcus pneumoniae and viral mimetic
Irene Heijink (Groningen, Netherlands), H. Irene Heijink, Marnix Jonker, Dirkje S. Postma, Maarten van den Berge
Congress or journal article abstractE-poster
Congress or journal article abstractE-poster
Pharmacological characterization of the anti-oxidant activity of N-acetylcysteine in an ex vivo model of COPD exacerbation
Paola Rogliani (Rome, Italy), Paola Rogliani, Josuel Ora, Luigino Calzetta, Gabriella Lucà, Maria Gabriella Matera, Mario Cazzola
Congress or journal article abstractE-poster
Congress or journal article abstractE-poster
Anti-inflammatory activity of the bradykinin B1R antagonist in a model of LPS-induced lung inflammation in cynomolgus monkey
Thierry Bouyssou (Warthausen, Germany), Thierry Bouyssou, Birgit Jung, Peter Nickolaus, Jeff Duan, Feihong Dai, Henri Doods
Congress or journal article abstractE-poster
Congress or journal article abstractE-poster
Effect of high, medium, and low molecular weight hyaluronan on inflammation and oxidative stress in an in vitro model of human nasal epithelial cells
Mirella Profita (Palermo, PA, Italy), Giusy D. Albano, Anna Bonanno, Luca Cavalieri, Eleonora Ingrassia, Caterina Di Sano, Liboria Siena, Loredana Riccobono, Rosalia Gagliardo, Mirella Profita
Congress or journal article abstract
Congress or journal article abstract
The combination of TNF-α neutralization and dexamethasone treatment restored the corticosteroid responsiveness in tobacco smoking mice
Yuki Nishimoto (Chiba, Japan), Yuki Nishimoto, Genki Kimura, Keitaro Ueda, Takahiro Nakaoki, Kazuhiro Ito, Yasuo Kizawa
Congress or journal article abstract
Congress or journal article abstract
Alpha-7 nicotinic receptor stimulation reduces airway inflammation in a murine model of asthma
Carla Prado (Santos, Brazil), Fernanda Paula Roncon Santana, Cláudia Jeane Claudino de Pontes Miranda, Nathália Montouro Pinheiro, Adenir Perini, Luciana Chagas Caperuto, Iolanda de Fátima Lopes Calvo Tibério, Marco Antônio Maximo Prado, Milton de Arruda Martins, Vânia Ferreira Prado, Carla Máximo Prado
Congress or journal article abstract
Congress or journal article abstract
WNT-4 regulates pro-inflammatory responses driven by epithelial-mesenchymal cross-talk
Anita I. R. Spanjer (Groningen, Netherlands), Anita I.R. Spanjer, Eline M. van Dijk, Jacobien A. Noordhoek, Corry-Anke Brandsma, Wim Timens, Dirkje S. Postma, Herman Meurs, Reinoud Gosens, Irene H. Heijink
Congress or journal article abstract
Congress or journal article abstract
Maintenance of IRF1 by MAPK inhibition: A mechanism by which DUSP1 reduces glucocorticoid inhibition of CXCL10
Robert Newton (Calgary, AB, Canada), Suharsh Shah, Mahmoud Mostafa, Mohammed Altonsy, Robert Newton
Congress or journal article abstract
Congress or journal article abstract
Central role for the TRPV4-ATP-P2X3 axis in sensory nerve activation and the late asthmatic response
Mark Birrell (London, United Kingdom), Mark Birrell, Sara J. Bonvini, Katie E. Baker, Bilel Dekkak, Anthony Ford, Montse Miralpeix, Gema Tarrason, Jaclyn A. Smith, Maria G. Belvisi
Congress or journal article abstract
Congress or journal article abstract
TRPM3: A regulator of airway sensory nerves and respiratory reflexes
Sara Bonvini (London, United Kingdom), Sara Bonvini, Maham Arshad, Michael A. Wortley, John J. Adcock, Eric Dubuis, Kassandra Kosmidou, Sarah A. Maher, Fisnik Shala, Joris Vriens, Thomas Voets, Mark A. Birrell, Maria G. Belvisi
Congress or journal article abstract
Congress or journal article abstract
Direct activation of sensory afferents by diesel exhaust particles can trigger respiratory symptoms
Ryan Robinson (London, United Kingdom), Ryan Robinson, Mark Birrell, Michael Wortley, Eric Dubuis, Shu Chen, Catriona McGilvery, Sheng Hu, Sara Bonvini, Sarah Maher, John Adcock, Ian Mudway, Alexandra Porter, Terry Tetley, Maria Belvisi
Congress or journal article abstract
Congress or journal article abstract