European Respiratory Society Monograph, Vol. 81. 2018
ISBN (electronic): 978-1-84984-098-9
10.1183/2312508X.erm8118
Bronchiectasis is a hot topic in respiratory medicine, attracting an increasing amount of interest from clinicians, scientists, physiotherapists and the pharmaceutical industry. However, there is a lack of knowledge about the disease in terms of the research performed, clinical management, classification and patient treatment. The disease is also very complex because it can be caused by multiple underlying disorders, meaning its clinical presentation is highly diverse. This Monograph will tackle these issues by providing a series of chapters from recognised world experts covering: clinical management, service delivery, pathophysiology, microbiology and underlying disorders. The book also addresses the challenges faced in clinical trials and the need for drug development, and presents a number of clinical cases designed to aid learning. The Bronchiectasis Monograph substantially integrates the 2017 ERS guidelines on management of these patients. It is an essential reference for anyone caring for bronchiectasis patients or engaged in bronchiectasis research.
Preface Robert Bals Eur Respir Monogr 2018; 81: ix |  |
Guest Editors
Eur Respir Monogr 2018; 81: x-xii |  |
Introduction James D. Chalmers, Eva Polverino, Stefano Aliberti Eur Respir Monogr 2018; 81: xiii-xiv |  |
List of abbreviations
Eur Respir Monogr 2018; 81: xvii |  |
A patient's perspective Marta Almagro Manero, Jeanette Boyd Eur Respir Monogr 2018; 81: 1-7 |   |
Pathophysiology Rita Boaventura, Amelia Shoemark, James D. Chalmers Eur Respir Monogr 2018; 81: 8-28 |   |
Identifying undiagnosed cystic fibrosis in adults with bronchiectasis Carlo Castellani, Nicholas J. Simmonds Eur Respir Monogr 2018; 81: 29-44 |   |
Comorbidities and their impact Melissa J. McDonnell, Chris Ward, Robert M. Rutherford Eur Respir Monogr 2018; 81: 45-61 |   |
Defining severe bronchiectasis Josje Altenburg, Pieter C. Goeminne Eur Respir Monogr 2018; 81: 62-81 |   |
The bronchiectasis microbiome Geraint B. Rogers Eur Respir Monogr 2018; 81: 82-98 |   |
How do we know what works? Clinical trial end-points and quality of life assessment William R. Good, Lata Jayaram, Alain C. Vandal, Conroy A. Wong Eur Respir Monogr 2018; 81: 99-132 |   |
Phenotypes and endotypes James D. Chalmers Eur Respir Monogr 2018; 81: 133-152 |   |
Primary immunodeficiency David M. Lowe, John R. Hurst Eur Respir Monogr 2018; 81: 153-166 |   |
COPD and asthma overlap with bronchiectasis Federico L. Dente, Maria Adelaide Roggi, Roberta Del Cesta, Eva Polverino, Pierluigi Paggiaro Eur Respir Monogr 2018; 81: 167-185 |   |
Fungal lung disease Heather Green, Pippa Newton, Andrew M. Jones Eur Respir Monogr 2018; 81: 186-203 |   |
Diagnosis, classification and epidemiology of pulmonary nontuberculous mycobacterial disease Timothy M. Baird, Rachel Thomson Eur Respir Monogr 2018; 81: 204-221 |   |
Management of pulmonary nontuberculous mycobacteria disease Steven Cowman, Michael R. Loebinger Eur Respir Monogr 2018; 81: 222-237 |   |
Nontuberculous mycobacteria infections in patients receiving immunosuppressive agents Gregory P. Ranches, Kevin L. Winthrop Eur Respir Monogr 2018; 81: 238-253 |   |
Systemic and connective tissue diseases Anthony De Soyza Eur Respir Monogr 2018; 81: 254-266 |   |
Diagnosis of primary ciliary dyskinesia: current practice and future perspectives Amelia Shoemark, Jane S. Lucas Eur Respir Monogr 2018; 81: 267-281 |   |
Management of primary ciliary dyskinesia: current practice and future perspectives Claudia E. Kuehni, Myrofora Goutaki, Bruna Rubbo, Jane S. Lucas Eur Respir Monogr 2018; 81: 282-299 |   |
Management of frequently exacerbating patients Andrea Gramegna, Marta Di Pasquale, Francesco Blasi Eur Respir Monogr 2018; 81: 300-311 |   |
Antibiotic management and resistance Eva Polverino, Javier Perez-Miranda Eur Respir Monogr 2018; 81: 312-330 |   |
Airway clearance techniques, pulmonary rehabilitation and physical activity Beatriz Herrero-Cortina, Annemarie L. Lee, Brenda O'Neill, Judy Bradley Eur Respir Monogr 2018; 81: 331-352 |   |
Site of care and multidisciplinary approach Francesco Amati, Andrea Gramegna, Martina Contarini, Paolo Tarsia, Angela Bellofiore, Francesco Blasi, Stefano Aliberti Eur Respir Monogr 2018; 81: 353-370 |   |
Future directions: the next 10 years in research Sanjay H. Chotirmall Eur Respir Monogr 2018; 81: 371-387 |   |
Case 1 Andrea Gramegna Eur Respir Monogr 2018; 81: 388-390 |   |
Case 2 Diego Jose Maselli Eur Respir Monogr 2018; 81: 391-395 |   |
Case 3 Jessica Rademacher Eur Respir Monogr 2018; 81: 396-398 |   |
Case 4 Margarida Redondo Eur Respir Monogr 2018; 81: 399-402 |   |
Case 5 Patricia Chang-Macchiu, Eva Polverino Eur Respir Monogr 2018; 81: 403-408 |   |
Case 6 Guillermo Suarez-Cuartin Eur Respir Monogr 2018; 81: 409-412 |   |